Table 2.
VR + TAU | TAU | Group effect on pre-post difference score (t or U, p)c | Group effect on pre-test to follow-up difference score (t or U, p)c | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Primary Outcomea | Pre-test | Post-test | Follow-up | Pre-post difference scoreb | Effect size db | Pre-test | Post-test | Follow-up | Pre-post difference scoreb | Effect size db | ||
Motor | ||||||||||||
BBT-MAH | 21.8 (12.8) | 39.1 (14.5) | 40.8 (15.5) | 17.3 (8.6), p < 0.001 | 1.3 | 21.5 (8.1) | 29.8 (11.2) | 30.9 (11.5) | 8.4 (5.3), p < 0.001 | 0.9 | 21.50, 0.008* | 23.00, 0.011* |
BBT-LAH | 45.1 (7.9) | 57.6 (5.4) | 60.6 (5.6) | 12.5 (7.7), p = 0.001 | 1.9 | 44.5 (8.3) | 50.9 (8.2) | 50.9 (7.8) | 6.5 (5.7), p = 0.004 | 0.8 | 2.05, 0.054 | −3.44, 0.003* |
BBT Total | 66.9 (14.1) | 96.7 (12.6) | 101.4 (14.7) | 29.8 (11.5), p < 0.001 | 2.2 | 65.9 (10.3) | 80.7 (11.9) | 81.8 (11.4) | 14.8 (7.8), p < 0.001 | 1.3 | 3.52, 0.002* | 9.50, < 0.001* |
Cognitive | ||||||||||||
MoCA | 18.4 (2.50) | 24.8 (2.6) | 25.4 (2.6) | 6.40 (1.3), p < 0.001 | 2.5 | 19.2 (4.0) | 21.4 (3.6) | 21.8 (3.5) | 2.2 (0.9), p = 0.004 | 0.6 | 0.50, < 0.001* | − 7.41, < 0.001* |
GMLT Errors | 107.8 (12.3) | 87.5 (9.5) | 76.1 (10.5) | 20.3 (8.4), p < 0.001 | 1.9 | 110.6 (14.7) | 108.0 (13.2) | 101.1 (14.5) | 2.5 (6.1), p = 0.198 | 0.2 | −5.57, < 0.001* | 4.32, < 0.001* |
Set Shift Errors | 64.9 (10.1) | 46.9 (6.2) | 33.3 (7.0) | 18.0 (10.3), p < 0.001 | 2.2 | 64.6 (12.7) | 61.0 (11.5) | 58.9 (12.6) | 3.5 (6.1), p = 0.082 | 0.3 | −3.95, 0.001* | 7.43, < 0.001* |
aMean (SD); bwithin-group dependent t-test comparison of pre-test vs. post-test; cbetween-group independent t-test comparison of VR+TAU vs. TAU; * p < Benjamini-Hochberg critical value. BBT Box and Blocks Test, GMLT CogState Groton Maze Learning Task, LAH Less Affected Hand, MAH Most Affected Hand, MoCA Montreal Cognitive Assessment, TAU Treatment as Usual, VR Virtual Rehabilitation