Table 3.
Top genes with > 10 mutations in PDAC tumors from TCGA (provisional, accessed January 17, 2014)
| Gene | Cytoband | Gene size (Nucleotides) | n. Mutations |
|---|---|---|---|
| TP53 | 17p13.1 | 3924 | 37 |
| PCDHGC5 | 5q31 | 4641 | 36 |
| KRAS | 12p12.1 | 7302 | 33 |
| ZFHX3 | 16q22.3 | 17,503 | 26 |
| PCDHAC2 | 5q31 | 5970 | 26 |
| TCF20 | 22q13.3|22q13.3 | 7548 | 24 |
| CHD3 | 17p13.1 | 9758 | 16 |
| PCDH15 | 10q21.1 | 14,967 | 16 |
| GIGYF1 | 7q22 | 6709 | 15 |
| PCDH10 | 4q28.3 | 5516 | 15 |
| ANK3 | 10q21 | 22,521 | 14 |
| MED15 | 22q11.2 | 10,374 | 14 |
| GZF1 | 20p11.21 | 5495 | 14 |
| KIAA0907 | 1q22 | 5635 | 14 |
| TTBK2 | 15q15.2 | 11,642 | 13 |
| SUPT6H | 17q11.2 | 10,615 | 13 |
| GRM1 | 6q24 | 7272 | 13 |
| CDKN2A | 9p21 | 4400 | 13 |
| RANGAP1 | 22q13 | 5463 | 13 |
| CHD4 | 12p13 | 7474 | 12 |
| ZFC3H1 | 12q21.1 | 9670 | 12 |
| TAOK2 | 16p11.2 | 9058 | 12 |
| SIPA1L1 | 14q24.2 | 12,412 | 12 |
| HOXA1 | 7p15.3 | 2539 | 12 |
| PASD1 | Xq28 | 4429 | 12 |
| NOS1AP | 1q23.3 | 8449 | 12 |
| ZMIZ1 | 10q22.3 | 10,735 | 12 |
| TMCC1 | 3q22.1 | 7912 | 12 |
| MAMLD1 | Xq28 | 5958 | 12 |
| SMARCC2 | 12q13.2 | 8555 | 11 |
| CDH10 | 5p14.2 | 3660 | 11 |
| FTSJ3 | 17q23.3 | 5213 | 11 |
| MUC4 | 3q29 | 21,325 | 11 |
| MED12L | 3q25.1 | 12,619 | 11 |
| TCHH | 1q21.3 | 6900 | 11 |
| MAGEC1 | Xq26 | 4270 | 11 |
| NAV2 | 11p15.1 | 14,577 | 11 |
| RSPH6A | 19q13.3 | 2547 | 11 |
| FUZ | 19q13.33 | 2951 | 11 |
| SF3A1 | 22q12.2 | 6327 | 11 |
| CDC27 | 17q21.32 | 6823 | 11 |
| FOXN3 | 14q31.3 | 11,033 | 11 |
| CXXC1 | 18q12 | 4319 | 11 |