Table 2.
Multivariate survival analysis
| Variables | Hazard ratio | 95% CI | P value |
|---|---|---|---|
| Overall survival | |||
| pTNM | 1.955 | 1.429–2.673 | < 0.001 |
| Lymphatic invasion | 1.719 | 1.126–2.624 | 0.012 |
| Venous invasion | 1.349 | 0.936–1.946 | 0.109 |
| Perineural invasion | 1.228 | 0.862–1.750 | 0.255 |
| p53 expression status | 0.877 | 0.599–1.285 | 0.501 |
| L1 methylation | 0.566 | 0.381–0.841 | 0.005 |
| Disease-free survival | |||
| pTNM | 1.963 | 1.435–2.684 | < 0.001 |
| Lymphatic invasion | 1.758 | 1.149–2.689 | 0.009 |
| Venous invasion | 1.329 | 0.918–1.924 | 0.132 |
| Perineural invasion | 1.145 | 0.806–1.628 | 0.449 |
| p53 expression status | 0.859 | 0.587–1.255 | 0.432 |
| L1 methylation | 0.979 | 0.962–0.996 | 0.015 |