Table 3.
AUCSS, τ [h*ng/ml], CSS, max [ng/ml], and CSS, min [ng/ml] for each treatment and nutrition condition (PP; n = 21)
Ciclosporin Pro | Sandimmun Optoral | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
fasting | high-fat | fasting | high-fat | |||||||||
Geom. mean | 95% CI | CV % | Geom. mean | 95% CI | CV % | Geom. mean | 95% CI | CV % | Geom. mean | 95% CI | CV % | |
AUC | 3006.5 | [2652.7;3407.5] | 28.0 | 2652.7 | [2334.5;3014.2] | 28.6 | 3228.6 | [2857.8;3647.6] | 27.3 | 2711.2 | [2357.7;3117.7] | 31.4 |
Cmax | 844.6 | [702.4;1015.7] | 42.2 | 570.9 | [463.6;703.2] | 48.3 | 940.6 | [802.7;1102.3] | 35.9 | 560.2 | [454.3;690.8] | 48.6 |
Cmin | 97.9 | [87.1;110.1] | 26.2 | 91.4 | [81.1;103.0] | 26.7 | 100.0 | [88.8;112.5] | 26.4 | 97.7 | [86.9;109.9] | 26.2 |