Table 4.

Difference between Ciclosporin Pro and Sandimmun® Optoral in ln-transformed nutrition effects (PP, n = 21)

PK parameter	DCiclosporin Pro – DSandimmun Optoral Mean [SD]	DCiclosporin Pro – DSandimmun Optoral [97.5% CI]	Testing of H0*
			t-value	p-value**
CSS, max	0.1266 [0.6248]	[−0.1578; Infinity]	0.93	0.1820
AUCSS, τ	0.0494 [0.2850]	[−0.0803; Infinity]	0.79	0.2180
CSS, min	−0.0464 [0.3271]	[−0.1953; Infinity]	− 0.65	0.7384

Bold entries are significant

* Testing of H₀ (0 ≥ D_{Ciclosporin Pro} - D_{Sandimmun Optoral}) by means of the one-sided paired t-test (α = 0.025)

** lowest (one-sided) significance level, for which the null hypothesis could be rejected