Table 7.
Cociter analysis of top 30 prostate cancer driver genes identified by our method
| Genes | Driver | Prostate | Cancer | Is_driver | Ours | Diffusion | Muf_max | Muf_sum | IntDriver | Driver Net | Dawn Rank |
|---|---|---|---|---|---|---|---|---|---|---|---|
| TP53 | 110 | 298 | 6772 | 1 | 1 | 2 | 108 | 4 | 3 | 1 | 1 |
| SPOP | 4 | 24 | 43 | 1 | 2 | 1711 | 13 | 3 | 2 | 4 | 115 |
| TTN | 2 | 0 | 10 | 0 | 3 | 1713 | 2 | 2 | 1 | 25 | 51 |
| FOXA1 | 10 | 69 | 182 | 1 | 4 | 10 | 109 | 17 | 6 | 5 | 2 |
| MUC16 | 1 | 8 | 338 | 1 | 5 | 1712 | NA | NA | 4 | 76 | 184 |
| ATM | 5 | 61 | 1377 | 1 | 6 | 17 | 110 | 18 | 9 | 11 | 18 |
| CTNNB1 | 44 | 170 | 2517 | 1 | 7 | 1 | 112 | 16 | NA | 2 | 21 |
| OBSCN | 0 | 0 | 7 | 0 | 8 | 1705 | 1 | 22 | 50 | 174 | 417 |
| SPTA1 | 1 | 0 | 3 | 1 | 9 | 1702 | NA | NA | 8 | 15 | 6 |
| MUC17 | 0 | 0 | 9 | 0 | 10 | 1710 | NA | NA | 16 | 58 | 4 |
| PLCB4 | 3 | 0 | 4 | 0 | 11 | 14 | NA | 27 | NA | 13 | NA |
| EGFR | 166 | 144 | 4748 | 1 | 12 | 3 | 120 | 24 | NA | 6 | NA |
| LRP1B | 2 | 1 | 17 | 0 | 13 | 1681 | NA | 21 | 20 | 230 | NA |
| BRCA1 | 22 | 156 | 4652 | 0 | 14 | 7 | 134 | 47 | NA | 7 | 23 |
| FAT3 | 1 | 1 | 1 | 0 | 15 | 26 | NA | NA | 5 | 35 | 65 |
| PIK3CA | 54 | 34 | 1199 | 1 | 16 | 5 | NA | 31 | 53 | 9 | NA |
| KMT2C | 4 | 2 | 23 | 0 | 17 | 887 | NA | NA | 10 | 33 | NA |
| PTEN | 64 | 642 | 3047 | 1 | 18 | 715 | 111 | 25 | 38 | 147 | NA |
| RP1 | 1 | 0 | 9 | 0 | 19 | NA | NA | NA | 31 | NA | 695 |
| PIK3R2 | 2 | 5 | 25 | 0 | 20 | 4 | NA | NA | NA | 8 | NA |
| UBC | 2 | 10 | 134 | 0 | 21 | 13 | 28 | 1 | NA | 3 | NA |
| BRAF | 126 | 33 | 2175 | 1 | 22 | 245 | NA | 35 | 14 | 57 | 22 |
| KMT2D | 2 | 2 | 25 | 0 | 23 | 409 | NA | NA | 13 | 61 | NA |
| SMAD4 | 14 | 41 | 759 | 0 | 24 | 6 | NA | 135 | NA | 17 | 42 |
| ROCK1 | 2 | 17 | 150 | 0 | 25 | 70 | NA | 88 | NA | 64 | NA |
| HDAC3 | 2 | 11 | 100 | 0 | 26 | 46 | 143 | 147 | NA | 21 | NA |
| HSPA8 | 1 | 9 | 96 | 0 | 27 | 12 | 114 | 40 | NA | 14 | NA |
| GLI1 | 9 | 41 | 403 | 0 | 28 | 9 | NA | 108 | NA | 41 | 54 |
| APC | 21 | 59 | 2016 | 1 | 29 | 11 | NA | NA | 183 | 71 | NA |
| SP1 | 3 | 38 | 393 | 0 | 30 | 8 | 130 | 20 | NA | 12 | NA |
The first to the fourth column show the co-appeared counts of top 30 identified genes with ‘driver’, ‘prostate’ and ‘cancer’ (from the left to the right). Is_driver indicates whether the given gene is a driver gene or not. The left columns represent the rank positions of identified genes in Subdyquency, Diffusion, Muf_max, Muf_sum, IntDriver, DriverNet and DawnRank respectively