Table 8.

Number of driver genes with low or high variation frequency identified by our method and six other existing methods

		Top genes	Ours	Diffusion	DriverNet	Muf_max	Muf_sum	IntDriver	DawnRank
Low Frequency	Breast	50	0	1	0	0	1	0	0
		100	0	2	0	0	2	0	0
		150	0	2	0	0	2	0	0
		200	2	2	1	0	4	0	1
	Lung	50	0	0	1	0	0	0	0
		100	0	3	1	0	2	0	2
		150	1	3	2	2	2	0	4
		200	1	4	2	7	2	0	5
	Prostate	50	3	4	2	2	2	2	1
		100	3	4	4	2	2	3	1
		150	3	5	3	6	2	3	1
		200	3	7	5	6	2	3	2
High Frequency	Breast	50	25	11	17	13	13	13	16
		100	32	26	29	20	21	20	22
		150	40	33	39	26	29	26	28
		200	43	41	40	27	38	31	34
	Lung	50	21	15	15	9	11	8	10
		100	32	22	23	12	19	16	19
		150	39	26	27	12	27	20	22
		200	43	35	29	12	30	29	25
	Prostate	50	15	6	9	1	12	10	7
		100	20	8	14	1	16	11	9
		150	21	10	16	10	19	12	11
		200	23	13	17	10	20	14	13

The table shows the number of driver genes identified by our method and other six methods with low variation frequency (mutated less or equal to three samples) or high variation frequency (mutated more than three samples) for each cancer type