Table 4.
Comparison of TMB status in ADC and SQCC study groups
| Characteristic | ADC | P value | SQCC | P value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| High (n, %) |
Low/Moderate (n, %) |
High (n, %) |
Low/Moderate (n, %) |
|||||||
| Age (years) | 0.805 | 1 | ||||||||
| <58 (< 60) # | 9 | 14% | 55 | 86% | 7 | 29% | 17 | 71% | ||
| ≥58 (≥60) | 9 | 13% | 63 | 87% | 7 | 26% | 20 | 74% | ||
| Sex | 0.068 | 0.704 | ||||||||
| Male | 15 | 17% | 71 | 83% | 12 | 30% | 28 | 70% | ||
| Female | 3 | 6% | 47 | 94% | 2 | 18% | 9 | 82% | ||
| Smoking status | 1 | 0.512 | ||||||||
| Never smoker | 15 | 14% | 94 | 86% | 11 | 31% | 25 | 69% | ||
| Smoker | 3 | 11% | 24 | 89% | 3 | 20% | 12 | 80% | ||
| Pathologic stage | 0.796 | 0.529 | ||||||||
| IIIB | 8 | 15% | 46 | 85% | 7 | 33% | 14 | 67% | ||
| IV | 10 | 12% | 72 | 88% | 7 | 23% | 23 | 77% | ||
| Mutation status | 0.049 | \ | ||||||||
| EGFR mutant | 4 | 7% | 54 | 93% | 0 | 0% | 2 | 100% | ||
| KRAS mutant | 5 | 29% | 12 | 71% | 2 | 100% | 0 | 0% | ||
| Other | 9 | 15% | 52 | 85% | 12 | 26% | 35 | 74% | ||
| PD-L1 in TC | ||||||||||
| Strong+ | 7 | 26% | 20 | 74% | 0.051 | 8 | 57% | 6 | 43% | 0.01 |
| Moderate/strong+ | 8 | 22% | 28 | 78% | 0.084 | 10 | 48% | 11 | 52% | 0.01 |
| Any+ | 9 | 18% | 41 | 82% | 0.293 | 11 | 39% | 17 | 61% | 0.058 |
| Negative | 9 | 10% | 77 | 90% | 3 | 13% | 20 | 87% | ||
| PD-L1 in IC | ||||||||||
| Strong+ | 6 | 22% | 21 | 78% | 0.199 | 1 | 8% | 11 | 92% | 0.141 |
| Moderate/strong+ | 6 | 18% | 28 | 82% | 0.389 | 1 | 7% | 13 | 93% | 0.076 |
| Any+ | 8 | 17% | 40 | 83% | 0.431 | 7 | 24% | 22 | 76% | 0.752 |
| Negative | 10 | 11% | 78 | 89% | 7 | 32% | 15 | 68% | ||
Note: #: for age of SQCC