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. 2019 May 14;19:129. doi: 10.1186/s12935-019-0845-7

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Knockdown of PKM2 expression enhanced the radiosensitivity of HeLa and SiHa cells in vitro. a, b Cells were irradiated at different doses of irradiation, and the CCK-8 assay was used to test the viability of these cells. c, d Radiation sensitivity was tested using colony formation assays. Knockdown of PKM2 decreased clonogenic formation in HeLa and SiHa cells compared with control. e, f Survival curves were obtained using a multitarget click mathematical model. Data represent three independent experiments. *P < 0.05, ***P < 0.001