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. 2019 May 14;19:129. doi: 10.1186/s12935-019-0845-7

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Knockdown of PKM2 induced G2/M-phase arrest and apoptosis. a Cell cycle distribution was measured through flow cytometry. Graphic representation of flow cytometry data showing percentage of cells in G1, S, and G2/M phase. b After irradiation (IR), cells were incubated for 48 h and measured through Annexin V-APC/7-AAD staining and flow cytometry. Knockdown of PKM2 significantly promoted cell apoptosis after radiation treatment. c Graphic representation of flow cytometry data showing percentage of cells in G1, S, and G2/M phases. *P < 0.05, ***P < 0.001. d Statistical images of cell apoptosis (*P < 0.05, **P < 0.01). e The proteins p-ATM, p-BRCA1, p-Chk1, p-Chk2, Cyclin B1, p-P53, and γ-H2AX were detected through Western blotting. GAPDH was used as an internal reference. Data represent three independent experiments. P phosphate