Table 2.

Overview of available 90 day and 2 year dietary studies on MSG in rodents

Study type	Species	Dose levels tested mg/kg bw/day	Effects	NOAEL mg/kg bw/day	Reference
90 days OECD TG 408 study	Rats	0/308/931/3,170 males 0/354/1,066/3,620 females	No test substance related effects	>3,170	[41]
90 days OECD TG 408 study	Rats	0/700/1,300/2,700 males 0/700/1,500/2,900 females	No test substance related effects	>2,700	[42]
2 years study	Mice	0/58/201 males 0/53/183 females	No effects but high mortality in all groups	>183	[43]
2 years study	Rats	0/450/900/1,800 males 0/580/1,160/2,320 females	No effects	>1,800	[44]
2 years study	Rats	0/59/133 males 0/33/73 females	No effects	>73	[45]
2 years study	Rats	0/231/481/975/1,982 males 0/268/553/1,121/2,311 females	No effects	>1,982	[46]