Figure 4.

Relationships between histopathological OARSI grade and maximum values of novel parameters describing cartilage damage (a–d) as well as both standard (e) and complex (f) roughness. Except for Tortuosity‐like parameter, most of these parameters show an exponential increase with cartilage damage, especially after grade 3, where fissures become complex/branched. However, when evaluating ratios between complex and simple volumes (g) and roughness (h), it can be appreciated that complex features are present from very early osteoarthritis (OARSI ≥ 2.0).