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. 2019 Mar 5;37(4):855–866. doi: 10.1002/jor.24245

Table 1.

Area Under the Curve Values for Calculated Global Parameters and Detected Reference Surface Features >0.90 (Gray) and <0.80 (Black)

Surface Continuity (0: n = 7, ≥1: n = 29) Fibrillation (0: n = 12, ≥ 1: n = 24) Fissures (0: n = 18, ≥1: n = 18)
AUC LCL UCL AUC LCL UCL AUC LCL UCL R 2 for Curve Fit
MVD max 0.92 0.79 0.99 0.97 0.87 1 0.94 0.83 0.99 0.5
MVD mean 0.89 0.62 0.98 0.94 0.78 1 0.9 0.76 0.97 0.44
MVD SD 0.93 0.79 0.99 0.98 0.88 1 0.94 0.81 0.98 0.48
IVD max 0.93 0.8 0.99 0.97 0.82 1 0.94 0.8 0.98 0.5
IVD mean 0.88 0.59 0.98 0.94 0.74 0.99 0.88 0.68 0.96 0.43
IVD SD 0.94 0.78 0.99 0.97 0.85 1 0.93 0.8 0.98 0.48
SHRS max 0.8 0.43 0.96 0.91 0.69 0.99 0.87 0.71 0.95 0.37
SHRS mean 0.84 0.61 0.96 0.92 0.77 0.98 0.89 0.73 0.97 0.43
SHRS SD 0.84 0.49 0.97 0.92 0.72 1 0.89 0.72 0.96 0.42
Tort max 0.71 0.3 0.91 0.86 0.53 0.97 0.78 0.57 0.9 0.15
Tort mean 0.73 0.27 0.91 0.86 0.59 0.97 0.83 0.65 0.94 0.19
Tort SD 0.72 0.32 0.92 0.87 0.58 0.98 0.82 0.62 0.93 0.25
δVoidV 0.81 0.62 0.93 0.91 0.78 0.98 0.87 0.69 0.95 0.26
Rq 0.91 0.78 0.98 0.95 0.79 0.99 0.94 0.81 0.98 0.46
CRq 0.91 0.75 0.98 0.95 0.8 1 0.94 0.82 0.98 0.48
δRq 0.75 0.56 0.89 0.89 0.72 0.96 0.87 0.7 0.96 0.24

Confidence limits (95%) (lower: LCL, upper: UCL) estimated by bootstrapping. The result suggests that normal surface structure (Surface Continuity score = 0), lack of fibrillation (Fibrillation score = 0) and lack of fissures (Fissure score = 0) can be sensitively and specifically (AUC>0.90) delineated from tissue with degeneration (Surface Continuity, Fibrillation or Fissure scores ≥ 1) by most of the experimental parameters, except for tortuosity and relative Rq. In the right most column R 2 values for exponential curve fit when comparing surface features and OARSI grade. AUC are shown for maximum (max), mean and standard deviation of Maximum Void Depth (MVD), Integral Void Depth (IVD), Shortest Route to Surface (ShRS), Tortuosity‐like parameter (Tort), simple (ISO 25178) roughness (Rq), roughness complex (CRq) as well as ratios between simple and complex roughness (δRq) and volume (δVoidV).