Table 2.

Exploratory network differences between different groups

	HC			RRMS			PPMS
	RC	95% CI	P values	RC	95% CI	P values	RC	95% CI	P values
Edge density
MS	−0.65	(−1.69 to 0.38)	0.210
RRMS	−0.71	(−1.84 to 0.42)	0.219
PPMS	−0.72	(−2.1 to 0.67)	0.310	−0.011	(−1.27 to 1.25)	0.987
SPMS	−0.45	(−1.78 to 0.88)	0.507	0.258	(−0.93 to 1.43)	0.670	0.27	(−1.12 to 1.66)	0.707
Global efficiency
MS	−71.23	(−129.47 to −13.00)	0.016
RRMS	−33.44	(−95.11 to 28.25)	0.287
PPMS	−85.82	(−161.6 to −9.96)	0.027	−52.38	(−121.08 to 16.34)	0.135
SPMS	−145.34	(−218.38 to −72.28)	0.0001	−111.90	(−176.47 to −47.31)	0.0008	−59.52	(−135.72 to 16.67)	0.126
Mean local efficiency
MS	−72.53	(−138.60 to −6.46)	0.031
RRMS	−30.21	(−100.16 to 39.74)	0.396
PPMS	−85.68	(−171.68 to 0.34)	0.051	−55.46	(−133.39 to 22.47)	0.162
SPMS	−158.42	(− 241.26 to −75.58)	0.0002	−128.21	(−201.44 to −54.96)	0.0007	−72.74	(−159.16 to 13.68)	0.099
Mean clustering coefficient
MS	−14.84	(−19.89 to −9.79)	< 0.0001
RRMS	−12.00	(−17.51 to −6.48)	< 0.0001
PPMS	−13.42	(−20.19 to −6.64)	0.0001	−1.42	(−7.55 to 4.73)	0.650
SPMS	−20.30	(−26.84 to −13.76)	< 0.0001	−8.30	(−14.07 to −2.52)	0.0033	−6.88	(−13.69 to −0.06)	0.037

Analysis of variance was performed. P values in bold denote statistical significance at p<0.05 when the groups on the left were compared with the reference group (top row) and adjusted for age, gender, lesion load and total intracranial volume.

HC, healthy controls; MS, multiple sclerosis; PPMS, primary progressive MS; RC, regression coefficient; RRMS, relapsing–remitting MS; SPMS, secondary progressive MS.