Table 2.
Demographic and clinical characteristics of participants with different severity of EPVS
| Variables | CSO-EPVS | BG-EPVS | ||||
|---|---|---|---|---|---|---|
| Low-grade | High-grade | P | Low-grade | High-grade | P | |
| N, % | 54 (49.5) | 55 (50.5) | – | 61 (56.0) | 48 (44.0) | – |
| Male, N (%) | 20 (37.0) | 32 (58.2) | 0.027 | 24 (39.3) | 28 (58.3) | 0.049 |
| Age, years | 68.74±8.18 | 70.95±10.02 | 0.212 | 67.82±8.93 | 72.44±8.93 | 0.009 |
| Hypertension, N (%) | 36 (66.7) | 36 (65.5) | 0.894 | 37 (60.7) | 35 (72.9) | 0.180 |
| Diabetes mellitus, N (%) | 15 (27.8) | 5 (9.1) | 0.012 | 10 (16.4) | 10 (20.8) | 0.552 |
| Hyperlipidemia, N (%) | 28 (51.9) | 29 (52.7) | 0.927 | 31 (50.8) | 26 (54.2) | 0.728 |
| Current smoker, N (%) | 10 (18.5) | 19 (34.5) | 0.058 | 13 (21.3) | 16 (33.3) | 0.159 |
| BMI, kg/m2 | 25.98±3.43 | 25.95±3.39 | 0.964 | 25.77±3.14 | 26.21±3.71 | 0.501 |
| Fazekas score | 3.00 (1.00, 5.00) | 3.00 (2.00, 5.00) | 0.591 | 3.00 (1.00, 4.00) | 4.00 (2.00, 5.00) | 0.015 |
| Ktrans (10–4min–1) | 0.24 (0.10, 0.38) | 0.26 (0.12, 0.37) | 0.880 | 0.59 (0.37, 0.83) | 0.90 (0.61, 1.14) | <0.001 |
| AUC | 3.72±1.18 | 3.96±1.22 | 0.292 | 10.31±2.72 | 11.55±2.76 | 0.022 |
| Vp (10–2) | 5.71±2.99 | 5.59±2.54 | 0.818 | 17.48±6.76 | 14.69±6.59 | 0.033 |
Note: Data are presented as mean ± standard deviation, median (interquartile range) or counts (%).
Abbreviations: EPVS, enlarged perivascular spaces; CSO, centrum semiovale; BG, basal ganglia; BMI, body mass index; Ktrans, BBB leakage rate; BBB, blood–brain barrer; AUC, area under the leakage curve; Vp, fractional blood plasma volume.