Table 3.
Leakage rate and fractional blood plasma volume in relation to severity of BG-EPVS
| Variables | CSO-EPVS OR (95%CI) | BG-EPVS OR (95%CI) | ||||||
|---|---|---|---|---|---|---|---|---|
| Model 1 | P | Model 2 | P | Model 1 | P | Model 2 | P | |
| Ktrans (10−4 min−1) | 1.84 (0.31–11.00) | 0.505 | 2.07 (0.27–16.23) | 0.487 | 4.84 (1.72–13.66) | 0.004 | 5.33 (1.95–14.60) | 0.003 |
| AUC | 1.19 (0.86–1.67) | 0.298 | 1.18 (0.81–1.74) | 0.222 | 1.16 (0.99–1.36) | 0.059 | 1.12 (0.95–1.32) | 0.222 |
| Vp (10–2) | 1.02 (0.88–1.18) | 0.786 | 1.00 (0.85–1.17) | 0.962 | 0.93 (0.87–0.99) | 0.030 | 0.93 (0.87–0.99) | 0.030 |
Notes: Model 1: bivariate logistic regression analyses with adjustment for age and sex. Model 2: bivariate logistic regression analyses with adjustment for all variables (including age, sex, hypertension, diabetes mellitus, hyperlipidemia, current smoker, BMI, and Fazekas score).
Abbreviations: EPVS, enlarged perivascular spaces; CSO, centrum semiovale; BG, basal ganglia; BMI, body mass index; Ktrans, BBB leakage rate; BBB, blood–brain barrier; AUC, area under the leakage curve; Vp, fractional blood plasma volume.