Table 5.
Multivariable linear regression analyses demonstrating relationships between pulmonary functional indices and total vessel volume and vessel heterogeneity metrics
| Dependent variable | Independent variable | Beta coefficient | 95% CI | P‐value | R2 |
|---|---|---|---|---|---|
| FEV1 | Normalized vessel volume (%) | −6.78 | −10.68, −2.87 | 0.001 | 0.21 |
| Vessel heterogeneity (1) | −126.45 | −518.05, 770.95 | 0.70 | ||
| FVC | Normalized vessel volume (%) | −11.61 | −15.40, −7.82 | <1 × 10−6 | 0.35 |
| Vessel heterogeneity (1) | −214.05 | −839.19, 411.08 | 0.50 | ||
| DLCO | Normalized vessel volume (%) | −5.58 | −8.16, −3.501 | 4 × 10−5 | 0.21 |
| Vessel heterogeneity (1) | −680.13 | −1103.32, −256.93 | 0.002 | ||
| KCO | Normalized vessel volume (%) | 1.13 | −2.83, 5.08 | 0.57 | 0.15 |
| Vessel heterogeneity (1) | −548.55 | −1198.28, 101.18 | 0.10 | ||
| TLC | Normalized vessel volume (%) | −12.63 | −15.28, −9.99 | <1 × 10−6 | 0.51 |
| Vessel heterogeneity (1) | −528.32 | −968.25, −88.39 | 0.01 | ||
| CPI | Normalized vessel volume (%) | 7.46 | 5.28, 9.65 | <1 × 10−6 | 0.34 |
| Vessel heterogeneity (1) | 558.28 | 231.26, 945.30 | 0.001 |
All models were adjusted for patient age, male gender, smoking status (never vs ever) and CT slice thickness (0.7 vs 1.0 mm).
CPI, composite physiologic index; CT, computed tomography; DLCO, diffusion capacity for carbon monoxide; FEV1, forced expiratory volume in the first second; FVC, forced vital capacity; KCO, transfer factor for carbon monoxide; TLC, total lung capacity.