Figure 2.

The effect of weight loss on Ki‐67 expression in the endometrium. Compared with baseline, at 2 months a lower Ki‐67 was observed in 29/41 (71%) women (range −1.3% to −60.3%); the remaining 11 (34%) showed static or higher Ki‐67 levels (range 2.5% to 49.6%). Women whose Ki‐67 increased during follow up (n = 11) either developed an abnormal endometrium (n = 3), underwent sampling during a different phase of the menstrual cycle (n = 2), or established regular menstruation after >6 months of amenorrhea (n = 2). Four cases were unexplained. (a) Ki‐67 scores in the bariatric surgery cohort at baseline and 2 months (−15.1% at 2 months, p = 0.009), and (b) at baseline and 12 months (−15.8% at 12 months, p = 0.034); (c) Ki‐67 scores in the menstrual cycle controlled bariatric surgery subgroup at baseline and 2 months (−11.24% at 2 months, p = 0.0028), and (d) at baseline and 12 months (−17.79% at 12 months, p = 0.016).