Figure 3.

Donor T‐reg depletion results in exacerbated autoantibody production and accelerated graft loss. Heart allografts from unmodified (WT) or T‐reg–depleted bm12 donor mice were transplanted into WT C57BL/6 mice and effector autoantibody responses (A) and allograft rejection (B) were assessed. Compared to unmodified donor hearts, donor T‐reg depletion results in acute allograft rejection (median survival time [MST] 14 days vs 78 days; *P < .01, log‐rank test), with markedly augmented recipient autoantibody responses (**P < .001, 2‐way ANOVA). Data expressed as mean ± SD, n = 4