Figure 2.

MC38‐Sia^null tumors display enhanced tumor growth in vivo. (a) MC38‐MOCK or MC38‐Sia^null cells were injected into C57Bl/6 mice (n = 14) and immunodeficient NOD.Cg‐Prkdc ^scid Il2rg ^rm1Wjl /SzJ (NSG) mice (n = 9). (b–d) Tumor growth was monitored and depicted as mean tumor size (b) or individual tumor growth curves (c and d). Data are representative of one (d) or three (c) independent experiments. Mean ± SEM; ***, p < 0.001; ns, not significant. [Color figure can be viewed at wileyonlinelibrary.com]