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Time course of blood-brain barrier disruption in collagenase and blood injection models. Bars represent Evans blue mean fluorescence intensity (MFI, ± S.E.M) at indicated time points in striata of mice receiving stereotactic injection of collagenase or blood (n = 7/condition). Sham mice (4/condition) received anesthesia and needle insertion only. *P < 0.05, **P < 0.001 v. mean value in blood injection group.
