Table 2.
ESIP MiQuit trial outputs for women and offspring: base case and probabilistic sensitivity analyses, life‐time horizon.
| Outcome | Base case (deterministic: no allowance for uncertainty) | Estimates from the probabilistic sensitivity analysis (incorporates uncertainty for model inputs) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Comparator | Experimental | Incremental | ||||||||||
| Comparator | Experimental | Incremental | Median | Interquartile range | Median | Interquartile range | Median | Interquartile range | ||||
| Maternal outcomes | ||||||||||||
| Quit rate at delivery (%) | 0.0196 | 0.0542 | 0.0346 | 0.0180 | 0.0119 | 0.0256 | 0.0529 | 0.0431 | 0.0646 | 0.0340 | 0.0214 | 0.0468 |
| Expected life years per mother | 25.1797 | 25.1827 | 0.0030 | 25.2003 | 25.1634 | 25.2340 | 25.2033 | 25.1670 | 25.2365 | 0.0028 | 0.0018 | 0.0041 |
| Expected QALYs per mother | 23.1165 | 23.1246 | 0.0081 | 23.1946 | 22.7342 | 23.5788 | 23.2028 | 22.7449 | 23.5866 | 0.0074 | 0.0045 | 0.0112 |
| Expected cost per mother (£) | 10 002.04 | 9988.28 | −13.76 | 10 033.81 | 9523.45 | 10 601.76 | 10 019.46 | 9509.49 | 10 587.53 | −13.44 | −20.29 | −6.99 |
| ICER per additional life year (£) | −4636.23 | −4423.80 | −5437.41 | −3448.47 | ||||||||
| ICER per additional QALY (£) | −1701.05 | −1619.91 | −2084.53 | −1229.48 | ||||||||
| ICER per additional quitter (£) | −397.70 | −384.84 | −461.88 | −298.00 | ||||||||
| Offspring outcomes | ||||||||||||
| Expected life years per infant | 24.0721 | 24.1020 | 0.0299 | 24.0787 | 23.9804 | 24.1722 | 24.1082 | 24.0143 | 24.1991 | 0.0291 | 0.0181 | 0.0410 |
| Expected QALYs per infant | 23.5449 | 23.5771 | 0.0322 | 23.5953 | 23.3523 | 23.7965 | 23.6282 | 23.3859 | 23.8282 | 0.0310 | 0.0194 | 0.0441 |
| Expected cost per infant (£) | 7805.18 | 7777.79 | −27.39 | 7337.74 | 6409.01 | 8772.84 | 7310.38 | 6380.97 | 8750.28 | −26.37 | −39.39 | −14.87 |
| ICER per additional life year (£) | −915.58 | −884.29 | −1104.35 | −679.31 | ||||||||
| ICER per additional QALY (£) | −850.36 | −823.64 | −1033.68 | −625.10 | ||||||||
| Combined per pregnancy outcomes (mother and offspring) | ||||||||||||
| Expected life years per pregnancy | 49.2519 | 49.2847 | 0.0329 | 49.2754 | 49.1683 | 49.3811 | 49.3091 | 49.2058 | 49.4090 | 0.0321 | 0.0200 | 0.0450 |
| Expected QALYs per pregnancy | 46.6614 | 46.7017 | 0.0403 | 46.7560 | 46.1134 | 47.3147 | 46.7935 | 46.1575 | 47.3575 | 0.0391 | 0.0245 | 0.0552 |
| Expected cost per pregnancy (£) | 20 915.76 | 20 876.48 | −39.28 | 20 677.53 | 19 251.01 | 22 428.84 | 20 638.17 | 19 212.41 | 22 383.83 | −38.37 | −56.96 | −21.46 |
| ICER per additional life year (£) | −1194.68 | −1150.13 | −1422.75 | −894.08 | ||||||||
| ICER per additional QALY (£) | −974.83 | −939.53 | −1156.12 | −737.99 | ||||||||
| ICER per additional quitter (£) | −1135.27 | −1114.32 | −1297.95 | −909.49 | ||||||||
| Cost‐offset analysis | ||||||||||||
| Cost savings ratio for maternal health‐care only (£) | 5.53 | 5.42 | 3.30 | 7.78 | ||||||||
| Cost savings ratio for offspring health‐care only (£) | 10.01 | 9.67 | 5.84 | 14.12 | ||||||||
| Cost savings ratio for combined health‐care only (£) | 13.92 | 13.65 | 8.02 | 19.98 | ||||||||
ESIP = Economics of Smoking in Pregnancy; QALY = quality‐adjusted life year; ICER = incremental cost‐effectiveness ratio.