Skip to main content
. Author manuscript; available in PMC: 2019 May 15.
Published in final edited form as: J Am Chem Soc. 2017 Aug 2;139(32):11207–11213. doi: 10.1021/jacs.7b05412

Figure 6.

Figure 6.

Examples of electrochemical biosensors that are thought to signal via binding-induced changes in electron transfer kinetics. These include sensors based on binding-induced changes in (A) a redox reporter’s ability to diffuse to the electrode surface; (B) redox-reporter reorganization energy, which in turn alters electron transfer kinetics; (C) through-DNA charge transfer; and (D) sterically induced changes in the efficiency with which a “scaffold mounted” redox reporter approaches the electrode surface.