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. 2019 Jan 30;37(5):609–622. doi: 10.1002/stem.2974

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© 2019 The Authors. stem cells published by Wiley Periodicals, Inc. on behalf of AlphaMed Press 2019

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Cluster 2 shows enrichment of genes involved in cholesterol/lipid metabolism, mitochondrial biogenesis and mitotic genes. (A): Pathway analysis of genes enriched in cluster 2 showing the cholesterol and lipid metabolism to be the predominant pathways. (B): Violin plot analysis showing higher expression of genes involved in cholesterol/lipid metabolism genes in cluster 2 compared with cluster 1 CRX⁺ cells. (C): Violin plot analysis showing higher expression of genes involved in mitochondrial biogenesis in cluster 2 compared with cluster 1 CRX⁺ cells. (D): Violin plot analysis showing higher expression of genes involved in mitosis genes in cluster 2 compared with cluster 1 CRX⁺ cells.