Figure 4.

PTOCT of targeted GNR with or without intravitreal anti-VEGF in vivo. (a) PT signal density from every eye in both experimental cohorts, paired by mouse (n = 7 mice). The results are ordered from greatest to least magnitude of difference with the horizontal axis numbers matching the eyes to those in Figure 3a. The statistical significance of the difference between the PBS and anti-VEGF eyes was assessed using a Wilcoxon signed-rank test. W = 27; P ≤ 0.05. (b, c) Representative images of OCT b-scans with overlaid lesion-associated photothermal signal, both from mouse 5. Panel (b) shows a lesion from the eye given the anti-VEGF injection, while panel (c) is from the PBS-injected control eye of the same mouse, which shows both a larger lesion and increased PT signal per pixel.