Figure 3.

Minimal optogenetic stimulation of glutamatergic inputs to ChIs from control and dopamine‐lesioned striata. (A) Averaged unitary (black) and non‐unitary (dark gray) responses using a minimal stimulation protocol where the presence or absence (light gray) of a response is stochastic. (B) Empirical probability density function (pdf) of the amplitude of the stochastically generated EPSCs (corresponding to the experiment depicted in panel A) is fit by a binomial mixture of Gaussian model. (C) Boxplot of unitary response extracted from the value of the first mode of the pdf fit to each experiment demonstrates a lack of difference between PfN and cortical synapses and a lack of change following dopamine depletion.