Table 1.
Demographics and CSF biomarkers by diagnostic group
| DLB (n = 41) | PD (n = 46) | AD (n = 35) | Controls (n = 78) | |
|---|---|---|---|---|
| Age (y), mean ± SD | 66.5 ± 6.1 | 62.8 ± 10.1i | 67.8 ± 6.3 | 64.4 ± 6.9 |
| Sex (male), n (%) | 35 (85.4%)g, j | 28 (60.9%)h | 33 (94.3%)g | 41 (52.6%) |
| Disease duration (y),a median (IQR) | 3 (2‐4) | 4 (2‐9) | 4 (3‐5) | NA |
| MMSE,b median (IQR) | 23 (19‐26)g, j | 29 (28‐30)h | 23 (18‐25)g | 29 (28‐30) |
| Aβ1‐42 (pg/mL), mean ± SD | 695 ± 275f, i, k | 917 ± 211c | 486 ± 194f | 926 ± 266 |
| t‐tau (pg/mL), median (IQR) | 325 (224‐431)g, h, j | 189 (157‐275)h | 588 (398‐787)f | 247 (174‐308) |
| p‐tau (pg/mL), median (IQR) | 53 (35‐66)h | 38 (28‐51)h | 75.0 (62‐99)f | 45 (35‐57) |
| t‐α‐syn (ng/mL),c mean ± SD | 1.4 ± 0.4f, h | 1.4 ± 0.3f, h | 2.0 ± 0.5 | 1.8 ± 0.6 |
| o‐α‐syn (pg/mL),d mean ± SD | 108 ± 34f | 120 ± 49f, h | 89 ± 30 | 72 ± 37 |
| pSer129‐α‐syn (pg/mL),e mean ± SD | 232 ± 79 | 258 ± 52 | 220 ± 61 | 235 ± 54 |
Data are expressed as mean ± SD, median (IQR), or n (%). Demographical differences between groups were analyzed using analysis of variance with post hoc Bonferroni tests (age), X2 tests (sex), and Kruskal‐Wallis with post hoc Mann‐Whitney U tests (MMSE, disease duration). Differences in CSF biomarker levels between groups were assessed with a GLM adjusted for age and sex. t‐Tau and p‐tau were log‐transformed, but are presented as raw data.
Aβ1‐42, amyloid‐β1‐42; AD, Alzheimer's disease; DLB, dementia with Lewy bodies; MMSE, Mini‐Mental State Examination; NA, not applicable; PD, Parkinson's disease; pSer129‐α‐synuclein, phosphorylated α‐synuclein protein at serine 129; p‐tau, tau phosphorylated at threonine 181; o‐α‐syn, oligomeric α‐synuclein; t‐α‐syn, total α‐synuclein; t‐tau, total tau protein.
AD, n = 35; DLB, n = 40; PD, n = 45.
Controls, n = 78; AD, n = 34; DLB, n = 40; PD, n = 46.
Controls, n = 77; AD, n = 34; DLB, n = 41; PD, n = 46.
Controls, n = 78; AD, n = 35; DLB, n = 41; PD, n = 42.
Controls, n = 75; AD, n = 33; DLB, n = 38; PD, n = 45.
P < 0.001 compared with controls.
P < 0.05 compared with controls.
P < 0.001 compared with AD.
P < 0.05 compared with AD.
P < 0.001 compared with PD.
P < 0.05 compared with PD.