Table 3.

Summary of findings of oscillatory activity in DS mouse models.

First author of the work	Year of publication	DS subjects (recording technique)	Main findings
Colas et al., 2004	2004	SOD1 and hAPP mice (EEG).	Increase in waking and a decrease in slow wave sleep before light transition as well as an increase in theta power in REM and waking.
Colas et al., 2008	2008	Ts1Cje and Ts65Dn mice (EEG).	Increased waking periods at the expense of non-REM sleep in Ts65Dn mice. Increased power in theta oscillations during sleep and a delayed sleep rebound after sleep deprivation in Ts65Dn mice. Limited sleep and EEG abnormalities, delayed sleep rebound after sleep deprivation in TsCje mice.
Cramer et al., 2015	2015	Ts65Dn mice slices (intracellular).	Reduced spontaneous excitatory and inhibitory synaptic inputs to somatosensory cortex L4 regular spiking pyramidal neurons. Reduced UP state duration in these cells. Decreased intrinsic excitability in these cells.
Ruiz-Mejias et al., 2016	2016	TgDyrk1A mice (LFP).	Decreased firing rates and gamma oscillations in prefrontal cortex of anesthetized and waking mice. Slower propagation of UP states in frontal cortex of anesthetized mice. Reduced inhibitory contacts to inhibitory cells.
Levenga et al., 2018	2018	Dp(16) 1Yey/+ mice (EEG).	Theta decreased –within the light phase- and beta increased in waking. Alpha and beta waves increased and delta decreased in NREM sleep. Beta increased in REM sleep. Increased time awakke at the expense of NREM sleep.