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Deficiency of CD40, the CD40–TRAF2/3/5 interaction and the CD40–TRAF6 interaction is protective in EAE. (A) Clinical EAE scores of MHCII–CD40–T2/3/5 −/− (n = 7), MHCII–CD40–T6 −/− (n = 7), CD40 −/− (n = 7) and WT (n = 7) mice 22 days after EAE induction. (B) Percentage body weight change compared with day 0. Mean ± SEM.
