Table 1.
List of polypeptides included in the HF1 classifier
| Polypeptide | Cases | Controls | ||||||
|---|---|---|---|---|---|---|---|---|
| ID | Mass [Da] | CE Time [min] | Percentage [%] | MA | Percentage [%] | MA | R | p‐Value (unadjusted) |
| 81272 | 2211.98 | 33.23 | 0 | 0 | 0.42 | 2.67 | 0 | 1.99E–03 |
| 129821 | 3333.36 | 19.42 | 0 | 0 | 0.47 | 2.39 | 0 | 8.72E–04 |
| 8725 | 949.4 | 25.79 | 0.05 | 1.94 | 0.63 | 2.28 | 0.067 | 2.22E–04 |
| 123106 | 3130.43 | 30.82 | 0.05 | 1.98 | 0.47 | 2.63 | 0.080 | 2.57E–03 |
| 1577 | 840.41 | 23.17 | 0.05 | 1.65 | 0.47 | 1.85 | 0.095 | 3.29E–03 |
| 103493 | 2658.22 | 19.5 | 0.05 | 3.36 | 0.47 | 3.29 | 0.109 | 4.71E–03 |
| 44146 | 1518.6 | 19.37 | 0.11 | 1.91 | 0.58 | 2.49 | 0.145 | 1.33E–03 |
| 4845 | 900.27 | 43.66 | 0.16 | 1.55 | 0.63 | 2.44 | 0.161 | 1.33E–03 |
| 37610 | 1421.59 | 38.71 | 0.11 | 1.73 | 0.53 | 1.87 | 0.192 | 6.07E–03 |
| 83441 | 2248.97 | 33.69 | 0.11 | 3.45 | 0.53 | 3.56 | 0.201 | 4.88E–03 |
| 74703 | 2087.84 | 19.42 | 0.11 | 2.64 | 0.53 | 2.7 | 0.203 | 6.76E–03 |
| 101157 | 2616.16 | 28.39 | 0.11 | 1.97 | 0.53 | 1.98 | 0.206 | 6.76E–03 |
| 103022 | 2649.2 | 34.85 | 0.16 | 2.52 | 0.68 | 2.56 | 0.232 | 2.50E–03 |
| 57360 | 1734.66 | 19.9 | 0.16 | 2.2 | 0.58 | 2.24 | 0.271 | 1.03E–02 |
| 46091 | 1554.66 | 28.59 | 0.16 | 2.08 | 0.53 | 2.24 | 0.280 | 1.18E–02 |
| 32022 | 1319.58 | 20.89 | 0.21 | 1.99 | 0.58 | 2.21 | 0.326 | 1.57E–02 |
| 102269 | 2638.18 | 28.42 | 0.26 | 2.3 | 0.68 | 2.49 | 0.353 | 1.26E–02 |
| 82708 | 2235.04 | 34.17 | 0.32 | 2.57 | 0.84 | 2.68 | 0.365 | 2.53E–03 |
| 188895 | 11967.55 | 20.47 | 0.26 | 2.68 | 0.63 | 2.94 | 0.376 | 9.50E–03 |
| 98089 | 2559.18 | 19.41 | 0.32 | 2.97 | 0.84 | 3 | 0.377 | 3.76E–03 |
| 138143 | 3593.47 | 20.2 | 0.26 | 2.67 | 0.68 | 2.68 | 0.381 | 1.50E–02 |
| 167786 | 4771.07 | 20.2 | 0.37 | 2.74 | 0.79 | 3.13 | 0.410 | 4.34E–03 |
| 61984 | 1835.71 | 19.91 | 0.53 | 2.64 | 1 | 3.12 | 0.448 | 1.33E–04 |
| 46369 | 1560.7 | 29.79 | 0.32 | 2.78 | 0.68 | 2.84 | 0.461 | 2.27E–02 |
| 143947 | 3801.77 | 33.46 | 0.37 | 2.26 | 0.79 | 2.24 | 0.473 | 2.67E–02 |
| 39275 | 1445.62 | 37.36 | 0.47 | 2.59 | 0.79 | 2.96 | 0.521 | 4.87E–03 |
| 56493 | 1716.66 | 20.18 | 0.47 | 2.56 | 0.79 | 2.74 | 0.556 | 2.11E–02 |
| 41972 | 1478.61 | 39.3 | 0.53 | 2.75 | 0.84 | 2.95 | 0.588 | 3.16E–03 |
| 24168 | 1195.48 | 37.51 | 0.58 | 2.8 | 0.84 | 3.26 | 0.593 | 3.12E–03 |
| 107858 | 2751.34 | 29.23 | 0.63 | 2.36 | 0.89 | 2.69 | 0.621 | 3.00E–03 |
| 23356 | 1179.52 | 37.49 | 0.58 | 2.63 | 0.84 | 2.9 | 0.626 | 2.67E–02 |
| 97599 | 2547.99 | 21.44 | 0.58 | 2.59 | 0.89 | 2.66 | 0.635 | 3.15E–02 |
| 8695 | 949.22 | 34.33 | 0.53 | 2.46 | 0.68 | 3.01 | 0.637 | 2.78E–02 |
| 23697 | 1186.53 | 22.39 | 0.68 | 2.8 | 1 | 2.88 | 0.661 | 2.08E–02 |
| 36566 | 1401.38 | 36.56 | 0.58 | 2.77 | 0.74 | 3.27 | 0.664 | 8.74E–03 |
| 153832 | 4196.75 | 20.84 | 0.68 | 2.41 | 0.95 | 2.59 | 0.666 | 4.93E–03 |
| 26670 | 1235.56 | 26.65 | 0.63 | 3.02 | 0.84 | 3.3 | 0.686 | 1.08E–02 |
| 58050 | 1749.81 | 30.61 | 0.63 | 2.57 | 0.84 | 2.79 | 0.691 | 3.04E–02 |
| 28005 | 1255.48 | 35.77 | 0.68 | 3.08 | 0.84 | 3.4 | 0.733 | 3.19E–02 |
| 159396 | 4409.89 | 20 | 0.74 | 2.72 | 0.84 | 3.23 | 0.742 | 2.68E–02 |
| 69979 | 1996.79 | 20.98 | 0.79 | 2.86 | 0.95 | 3.17 | 0.750 | 8.53E–03 |
| 40737 | 1462.62 | 39.42 | 0.84 | 3.33 | 1 | 3.68 | 0.760 | 2.62E–04 |
| 65368 | 1901.82 | 43.83 | 0.79 | 3.17 | 0.89 | 3.61 | 0.779 | 1.52E–02 |
| 128086 | 3286.55 | 30.92 | 0.79 | 3.13 | 0.89 | 3.51 | 0.792 | 6.91E–04 |
| 73434 | 2067.82 | 20.62 | 0.84 | 3.1 | 1 | 3.28 | 0.794 | 1.42E–02 |
| 148086 | 3986.65 | 20.6 | 0.84 | 3.53 | 0.95 | 3.82 | 0.817 | 2.75E–03 |
| 108574 | 2764.21 | 42.63 | 0.79 | 3.56 | 0.89 | 3.85 | 0.821 | 2.43E–02 |
| 90344 | 2377.1 | 20.8 | 0.89 | 3.12 | 0.95 | 3.46 | 0.845 | 1.95E–02 |
| 36759 | 1405.61 | 39.04 | 0.89 | 2.94 | 0.95 | 3.18 | 0.866 | 1.02E–02 |
| 147541 | 3968.6 | 21.09 | 0.89 | 3.14 | 0.89 | 3.57 | 0.880 | 1.77E–03 |
| 28561 | 1265.59 | 27.09 | 0.89 | 3.36 | 0.89 | 3.79 | 0.887 | 1.10E–02 |
| 107460 | 2742.25 | 28.98 | 0.95 | 2.91 | 1 | 3.11 | 0.889 | 1.19E–02 |
| 32171 | 1321.59 | 28.37 | 0.95 | 4.07 | 1 | 4.27 | 0.906 | 1.82E–02 |
| 39322 | 1446.64 | 39.43 | 1 | 3.2 | 1 | 3.49 | 0.917 | 3.19E–02 |
| 35339 | 1378.61 | 28.82 | 1 | 3.36 | 1 | 3.53 | 0.952 | 1.54E–02 |
| 81196 | 2210.95 | 33.61 | 1 | 3.72 | 1 | 3.59 | 1.036 | 2.15E–02 |
| 41601 | 1469.67 | 23.69 | 1 | 3.72 | 1 | 3.56 | 1.045 | 2.33E–02 |
| 62866 | 1854.81 | 40.92 | 1 | 3.89 | 1 | 3.71 | 1.048 | 1.98E–02 |
| 99021 | 2570.19 | 42.56 | 1 | 3.88 | 1 | 3.7 | 1.049 | 1.19E–02 |
| 79136 | 2175 | 33.28 | 1 | 3.74 | 1 | 3.49 | 1.072 | 1.09E–02 |
| 50840 | 1623.73 | 24.12 | 0.95 | 4.17 | 0.95 | 3.86 | 1.080 | 9.77E–03 |
| 72533 | 2046.92 | 32.58 | 0.95 | 3.49 | 0.95 | 3.21 | 1.087 | 1.06E–02 |
| 57537 | 1737.78 | 23.73 | 1 | 4.02 | 0.95 | 3.82 | 1.108 | 2.15E–02 |
| 50212 | 1613.82 | 23.99 | 0.89 | 2.7 | 0.89 | 2.43 | 1.111 | 3.30E–02 |
| 60149 | 1794.8 | 23.92 | 1 | 3.72 | 0.95 | 3.47 | 1.128 | 6.20E–03 |
| 103198 | 2654.19 | 23.92 | 0.89 | 2.94 | 0.89 | 2.47 | 1.190 | 5.52E–03 |
| 104786 | 2679.2 | 23.53 | 1 | 3.58 | 0.89 | 3.34 | 1.204 | 7.89E–03 |
| 33135 | 1338.6 | 23.99 | 1 | 2.86 | 0.89 | 2.65 | 1.213 | 1.20E–02 |
| 73291 | 2064.92 | 24.46 | 0.84 | 2.75 | 0.79 | 2.37 | 1.234 | 3.25E–02 |
| 45021 | 1532.62 | 26.35 | 1 | 2.82 | 0.89 | 2.55 | 1.243 | 1.67E–02 |
| 99475 | 2577.25 | 24.67 | 0.95 | 2.78 | 0.89 | 2.38 | 1.247 | 6.05E–03 |
| 40294 | 1452.66 | 23.61 | 1 | 2.85 | 0.84 | 2.62 | 1.295 | 2.17E–03 |
| 35424 | 1380.64 | 23.83 | 0.95 | 2.79 | 0.79 | 2.56 | 1.311 | 7.17E–03 |
| 131294 | 3375.57 | 31.92 | 1 | 2.87 | 0.79 | 2.71 | 1.341 | 1.80E–02 |
| 111564 | 2841.26 | 24.54 | 0.89 | 3.21 | 0.79 | 2.67 | 1.354 | 4.98E–03 |
| 104195 | 2663.2 | 23.51 | 0.89 | 2.61 | 0.74 | 2.29 | 1.371 | 2.07E–02 |
| 28747 | 1268.57 | 27.25 | 1 | 3.44 | 0.74 | 3.32 | 1.400 | 1.01E–02 |
| 44802 | 1526.69 | 23.92 | 0.79 | 2.51 | 0.63 | 2.1 | 1.499 | 1.10E–02 |
| 113452 | 2889.35 | 24.08 | 0.89 | 2.47 | 0.58 | 2.29 | 1.655 | 7.34E–03 |
| 69681 | 1989.88 | 32.44 | 0.84 | 2.43 | 0.42 | 2.51 | 1.936 | 2.03E–02 |
| 55516 | 1696.72 | 23.95 | 0.79 | 2.54 | 0.42 | 2.39 | 1.999 | 1.59E–02 |
| 80360 | 2196.02 | 33.16 | 0.68 | 2.74 | 0.26 | 2.73 | 2.625 | 1.15E–02 |
| 82784 | 2236.98 | 27.14 | 0.63 | 2.28 | 0.21 | 2.31 | 2.961 | 1.29E–02 |
| 56806 | 1723.52 | 37.74 | 0.53 | 2.31 | 0.11 | 2.52 | 4.417 | 1.03E–02 |
| 129182 | 3320.51 | 24.25 | 0.47 | 2.07 | 0.05 | 2.1 | 9.266 | 4.71E–03 |
ID, polypeptide identifier (SQL number); %, percentage of samples, in which the polypeptide could be detected; MA, mean signal amplitude of the polypeptides. R was calculated as ∑ (ln signal amplitude × frequency/number of participants) in controls divided by ∑ (ln signal amplitude × frequency/number of participants) in cases. The polypeptides were ordered by ascending R. Reproduced with permission from ref. 18.