Table 5.
Predictors of Negative Sputum Culture Conversion in Patients With Mycobacterium avium complex Lung Disease Treated With a Sitafloxacin-Containing Antibiotic Regimena
| Predictor | Sputum Culture Conversion, No. (%) of Patients | Univariate Analysis | Multivariate Analysis | |||
|---|---|---|---|---|---|---|
| Characteristics | Yes (n = 7) | No (n = 24) | OR (95% CI) | P Value | aOR (95% CI) | P Value |
| Age | ||||||
| ≥65 y | 5 (71) | 14 (58) | Reference | .53 | … | … |
| <65 y | 2 (29) | 10 (42) | 0.56 (.09–3.49) | … | ||
| Sex | ||||||
| Male | 2 (29) | 4 (17) | Reference | .50 | … | … |
| Female | 5 (71) | 20 (83) | 0.50 (.07–3.55) | … | ||
| BMI | ||||||
| ≤18.5 kg/m2 | 4 (57) | 15 (62) | Reference | .80 | … | … |
| >18.5 kg/m2 | 3 (43) | 9 (38) | 1.25 (.23–6.91) | … | ||
| Radiographic patterns | ||||||
| Other | 2 (29) | 12 (50) | Reference | .31 | … | |
| NB form | 5 (71) | 12 (50) | 2.50 (.40–15.5) | … | ||
| Cavitary lesion | ||||||
| Yes | 3 (43) | 17 (71) | Reference | .18 | … | … |
| No | 4 (57) | 7 (29) | 3.23 (.57–18.4) | … | ||
| Sputum smear for AFB | ||||||
| Positive | 5 (71) | 15 (62.5) | Reference | .67 | … | … |
| Negative | 2 (29) | 9 (37.5) | 0.67 (.11–4.18) | … | ||
| AMK use (injection or inhalation) | ||||||
| No | 3 (43) | 16 (67) | Reference | .26 | … | … |
| Yes | 4 (57) | 8 (33) | 2.67 (.48–14.9) | … | ||
| EMB or RIF MIC | ||||||
| ≥8 μg/mL | 3 (43) | 9 (37.5) | Reference | .80 | … | … |
| <8 μg/mL | 4 (57) | 15 (62.5) | 0.80 (.14–4.42) | … | ||
| Treatment duration | ||||||
| ≥12 mo | 6 (86) | 21 (87.5) | Reference | .90 | … | … |
| <12 mo | 1 (14) | 3 (12.5) | 1.17 (.10–13.4) | … | ||
| STFX dosage 200 mg/d | ||||||
| No | 0 (0) | 3 (12.5) | Reference | .20 | … | … |
| Yes | 7 (100) | 21 (87.5) | NA | … | ||
| Macrolide resistance | ||||||
| No | 1 (14) | 15 (62) | Reference | .02 | Reference | .001 |
| Yes | 6 (86) | 9 (38) | 10.0 (1.03–97.0) | NA | ||
| STFX MIC | ||||||
| >1 μg/mL | 0 (0) | 8 (33) | Reference | .03 | Reference | .01 |
| ≤1 μg/mL | 7 (100) | 16 (67) | NA | NA | ||
| Surgery | ||||||
| No | 4 (57) | 24 (100) | Reference | .001 | Reference | .003 |
| Yes | 3 (43) | 0 (0) | NA | NA | ||
Abbreviations: AFB, acid-fast bacilli; AMK, amikacin; aOR, adjusted odds ratio; BMI, body mass index; CI, confidence interval; EMB, ethambutol; MIC, minimum inhibitory concentration; NA, not available; NB, nodular/bronchiectatic; OR, odds ratio; RIF, rifampin; STFX, sitafloxacin.
aNo stable estimate was obtained because in all patients in whom the STFX MIC was >1 μg/mL, sputum culture conversion did not occur; sputum culture conversion occurred in all patients who underwent surgery; and sputum culture conversion occurred in patients who underwent surgery, whose STFX MIC was ≤1 μg/mL, or who had macrolide resistance.