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. 2019 Feb 19;6(1):e000294. doi: 10.1136/lupus-2018-000294

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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L-sepiapterin (L-sep) restores nitric oxide (NO) production in SLE sera cultured humanumbilical vein endothelial cells (HUVECs). (A) Representative histograms of DAF-FM fluorescence intensity measured in HUVECs cultured in control conditions (grey) or control conditions+L-sepiapterin (black) in the following order endothelial basal medium 2 (EBM-2) buffer (far left), healthy control serum (middle) and SLE serum (far right). (B) A column graph representing the mean fold change of the median fluorescence intensity normalised to buffer controls±SEM. Analysis was conducted using a two-way analysis of variance (ANOVA) with Fisher’s least significance difference post-hoc test. *p<0.05, **p<0.01. (C) A graph representing the mean fold change of L-sep/no L-sep for each serum treatment group. Analysis was conducted using a one-way ANOVA. ***p<0.001, compared with buffer control, ##p<0.01 compared with healthy control.