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. 2014 Sep 14;127(18):3943–3955. doi: 10.1242/jcs.147033

Fig. 1.

Fig. 1.

Effects of KCNE1 C-terminus deletions and LQT5 mutations on IKS currents. (A) A cartoon of KCNE1, indicating the location of the LQT5 mutations and the deletions in the C-terminus. Representative current traces of WT KCNQ1, co-expressed in CHO cells with WT KCNE1 (B), LQT5 mutant V109I (C), LQT5 mutant P127T (D) or with KCNE1 deletion mutants at the distal C-terminus Δ109–129 (E) or the proximal C-terminus Δ69–77 (F). Cells were held at −90 mV. Membrane voltage was stepped for 3 s from −50 mV to +60 mV (or to +100 mV for Δ69–77) in 10 mV increments and then repolarized for 1.5 s to −60 mV. Current–voltage (G) and conductance–voltage (H) relationships of WT KCNQ1+WT KCNE1 or LQT5 mutants (n = 11–17). Current–voltage (I) and conductance–voltage (J) relationships of WT KCNQ1+WT KCNE1 or deletion mutants (n = 7–10).