Table 4.

Impact of the change in resting heart rate 1993 to 2003 on outcome

	All-cause death			Cardiovascular disease			Coronary heart disease
	No events (%) ER (*1000 py)	HR (95% CI) P value		No events(%) ER (*1000 py)	HR (95% CI) P value		No events(%) ER (*1000 py)	HR (95% CI) P value
		Unadjusted	Adjusted		Unadjusted	Adjusted		Unadjusted	Adjusted
Increased RHR (n=111)	12 (10.8)	1 (ref)	1 (ref)	38 (34.2)	1 (ref)	1 (ref)	19 (17.1)	1 (ref)	1 (ref)
	5.1			16.3			8.2
Unchanged RHR (n=205)	15 (7.3) 3.4	0.65 (0.30 to 1.39) 0.265	0.71 (0.32 to 1.61) 0.417	44 (21.4) 10.2	0.54 (0.35 to 0.83) 0.005	0.56 (0.35 to 0.87) 0.011	20 (9.7) 4.6	0.53 (0.28 to 0.99) 0.047	0.64 (0.32 to 1.25) 0.636
Decreased RHR (n=338)	28 (8.3) 3.9	0.75 (0.38 to 1.47) 0.394	0.76 (0.37 to 1.59) 0.467	111 (32.9) 15.6	0.93 (0.65 to 1.35) 0.710	0.91 (0.61 to 1.34) 0.622	55 (16.3) 7.8	0.95 (0.57 to 1.60) 0.952	1.08 (0.60 to 1.92) 0.808

Adjusted for body mass index, systolic blood pressure, smoking, sedentary lifestyle, mental stress, NT-pro-BNP and eGFR.

ER, event rate (1000 per year); NT pro BNP, N-terminal prohormone of brain natriuretic peptide; py, person years;; RHR, resting heart rate.