TABLE I.
Comparison of immunologic parameters between CVID and IgG deficient patient cohorts
| CVID (total n = 128) |
IgG deficiency (total n = 124) |
p value | |
|---|---|---|---|
| Immunoglobulin level means (in mg/dl) | |||
| IgG (nl 767-1,590 mg/dL) | 255 (226 - 285) (n = 120) | 556 (527 - 584) (n =124) | <0.0001 |
| IgA (nl 61-356 mg/dL) | 19.8 (15.2 - 24.5) (n = 126) | 102 (90.0 - 113) (n = 124) | <0.0001 |
| IgM (nl 37-286 mg/dL) | 45.8 (31.6 - 60.0) (n = 126) | 99.5 (87.1 - 112) (n = 124) | <0.0001 |
| Percentage of patients with protective protein/conjugate serologic titers | |||
| Haemophilus influenzae B | 46.2 (30.3 - 62.1) (n = 39) | 66.3 (55.9 - 76.7) (n = 80) | 0.036 |
| Measles | 57.8 (43.2 - 72.4) (n = 45) | 88.5 (81.8 - 95.3) (n = 87) | <0.0001 |
| Mumps | 54.5 (39.6 - 69.4) (n = 44) | 80.9 (72.7 - 89.1) (n = 89) | 0.001 |
| Rubella | 84.4 (73.7 - 95.1) (n = 45) | 93.2 (87.9 - 98.5) (n = 88) | 0.11 |
| Tetanus | 63.3 (49.7 - 76.9) (n = 49) | 96.7 (93.1 - 100) (n = 88) | <0.0001 |
| Diphtheriaw | 71.1 (56.5 - 85.7) (n = 38) | 93.2 (87.3 - 99.0) (n = 73) | 0.001 |
| Varicella | 58.3 (42 - 74.6) (n = 36) | 93.4 (87.8 - 99.0) (n = 76) | <0.0001 |
| Sum of protective serologies to pneumococcal serotypes (means) | |||
| 3.08 (2.12 - 4.04) (n = 60) | 6.51 (5.78 -7.24) (n = 121) | <0.0001 | |
| T cell populations (absolute count means in cells/mm3) | |||
| CD3+ (nl 900- 2100) | 1209 (1070 - 1350) (n = 94) | 1344 (1150 - 1530) (n = 65) | 0.25 |
| CD3+CD4+ (nl 500-1500) | 680 (606 - 753) (n = 92) | 957 (812 - 1100) (n = 65) | 0.0004 |
| CD3+CD8+ (nl 150-1000) | 489 (403 - 574) (n = 92) | 362 (304 - 421) (n = 65) | 0.03 |
| B cells populations (means) | |||
| CD19+ (absolute, cells/mm3) nl = 74.4-441.1 | 205 (158 - 251) (n = 94) | 258 (202 - 313) (n = 67) | 0.15 |
| CD19+CD27+ (% of B cells) nl = 33.6-44.2 | 24.8 (20.9 - 28.8) (n = 111) | 41.0 (33.6 - 48.5) (n = 33) | 0.0002 |
| CD19+CD27+ (absolute cells/mm3) | 31.2 (22.4 - 40.0) (n = 85) | 97.5 (54.2 - 141) (n = 22) | <0.0001 |
| CD19+CD27+IgD- (% of B cells) nl = 20.8-24.3% | 2.85 (1.72 - 3.98) (n = 111) | 10.9 (8.28 - 13.4) (n = 33) | <0.0001 |
| CD19+CD27+IgD- (absolute, cells/mm3) | 3.65 (1.53 - 5.77) (n = 85) | 29.6 (16.5 - 42.7) (n = 22) | <0.0001 |