Scheme 3.
Scope and Comparison of Ligands/Conditions for Amide-Substituted Electrophiles
aYields determined by 1H NMR by comparison with an internal standard (1,2,4,5-tetramethylbenzene). Isolated yields in parentheses. Enantiomeric ratio determined by chiral HPLC in comparison to the racemate. P(2-Th)3 = tri(2-thienyl)phosphine.