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General catalytic cycle for P450 reactions.6,19 In some cases cytochrome b5 (b5) can donate the electron in step 4. b5 can also donate the electron in step 2 although not as efficiently because of the thermodynamic barrier. In some P450s (some bacterial and mitochondrial P450s) steps 2 and 4 involve electron donation from ferredoxin proteins. The exact electronic distribution in the Fe-O entities between steps 4–8 is not well established in most cases.
