TABLE 3.

Randomized Controlled Trials Examining Reverse Integration for Individuals With Serious Mental Illness

Study	Sample Size and Follow-Up	Medical Outcomes	Health Care Utilization and Cost
Druss et al, 2001 (46)	N=120, 12 months	Study participants had a significantly greater improvement in health, as measured by the Short-Form Health Survey.	Study participants attended more primary care visits, received a greater number of preventative services, and had fewer emergency department visits. There were no significant differences in cost between the two groups.
Druss et al, 2010 (47)	N=407, 12 months	Study participants had greater receipt of evidence-based cardiometabolic treatments and had lower Framingham Risk Scores at 12-month follow-up.	Study participants had greater receipt of preventative services. Individuals assigned care managers were also more likely to have a primary care provider. Cost was not studied.
Kilbourne et al, 2013 (28)	N=136, 12 months	Study participants had significant decreases in blood pressure but not in cholesterol. There were no statistically significant differences between groups in physical health-related quality of life.	Health care utilization and cost were not studied.
Druss et al, 2017 (48)	N=447, 12 months	Study participants showed significant improvements in quality of cardiometabolic care and a significant decrease in systolic blood pressure. There were no other significant differences in change in other cardiometabolic parameters.	Study participants had greater receipt of preventive services. Cost was not studied.