Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2020 Feb 14.

Published in final edited form as: J Med Chem. 2019 Feb 1;62(3):1138–1166. doi: 10.1021/acs.jmedchem.8b01090

Table 3.

IC₅₀ values [μM] and ligand efficiencies (LE) [(kcal/mol)/non-H-Atom] on HDAC6. Tub A = Tubastatin A.

	Compound
	Tub A	Tub A	1	18	22	7b	7c	7d

HA	25	25	25	24	26	27	26	29
IC₅₀, HDAC6	0.015²⁴	0.030	0.022	2.67	0.136	0.013	0.016	0.025
LE, HDAC6	0.44	0.43	0.43	0.33	0.37	0.41	0.43	0.37
	Compound
	7f	7e	7g	7h	7i	7j	7k	7p

HA	26	26	27	28	25	25	25	25
IC₅₀, HDAC6	0.012	0.077	0.010	0.031	0.005	0.007	0.017	0.011
LE, HDAC6	0.43	0.39	0.42	0.38	0.47	0.46	0.44	0.45
	Compound
	7l	7m	7n	7q	10p	10q	7o	14j

HA	25	25	25	26	25	26	25	26
IC₅₀, HDAC6	0.014	0.009	0.012	0.018	0.019	0.115	0.037	0.032
LE, HDAC6	0.45	0.46	0.45	0.42	0.44	0.38	0.42	0.41