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Quantification of Western blots in HL60 cells
| Compound | Ac-tubulin/GAPDH | Ac-H3/GAPDH | selectivity indexa |
|---|---|---|---|
| DMSO | 1.00b | 1.00b | |
| SAHA, 10 μM | 9.52 | 2.80 | 3.40 |
| SAHA, 1 μM | 9.97 | 1.91 | 5.22 |
| SAHA, 0.1 μM | 3.79 | 1.52 | 2.49 |
| 7i, 10 μM | 9.20 | 1.28 | 7.19 |
| 7i, 1 μM | 9.41 | 1.07 | 8.79 |
| 7i, 0.1 μM | 5.42 | 1.14 | 4.75 |
| 7n, 10 μM | 10.93 | 1.47 | 7.44 |
| 7n, 1 μM | 7.97 | 0.99 | 8.05 |
| 7n, 0.1 μM | 2.16 | 1.05 | 2.06 |
Selectivity index defined as quotient of Ac-tubulin/GAPDH divided by Ac-H3/GAPDH.
All values have been normalized to DMSO.
