Figure 3.

Estimation of microfluidic platform voltage sensitivity to hematocrit. (a) Model of a three component blood circuit between two co-planar electrodes. (b) Voltage profile of a RBC-capacitor contribution based on Ohm’s Law. (c) Illustration of RBC flow assumption for approximation of the time constant values (${\tau }_{H_x}$) as a function of hematocrit: Approximation 1 accounts for bulk flow of blood as a uniform colloid suspension, while Approximation 2 accounts for parabolic blood flow profiles and hematocrit-dependent viscosity. (d) Plot of approximated ${\tau }_{H_x}$ values as a function of hematocrit using Approximation 1 (grey line) or Approximation 2 (black line). The normal hematocrit range for men (40–54%) and women (36–48%) is highlighted with a grey box.