Table 1. Clinical inputs to the models.

^aThe Weibull survival function was assumed for the subgroups of exon 19 deletion and L858R mutation in the second‐line setting, and the parameters used were α_osimertinib = α_pc × HR and β_osimertinib = β_pc.

Abbreviations: CNS, central nervous system; EGFR, epidermal growth factor receptor; HR, hazard ratio; OS, overall survival; PC, pemetrexed plus cisplatin; PFS, progression‐free survival; SAE, serious adverse event (grade > 3); SOC, standard care.