Fig 2. Predictive ability of the UK Biobank variables for men and women.

Each point represents a variable in the UK Biobank ordered by the ability to predict CVD events for men and women. Predictions based solely on age achieved an AUC-ROC of 0.632 ± 0.003 for men and 0.665 ± 0.002 for women. We report the AUC-ROC from models trained with individual variables in addition to age, and only display variables that achieved a statistically significant improvement in AUC-ROC compared to predictions based on age only. Each color represents a different variable category. Variables deviating from the (dotted gray) regression line have an AUC-ROC that differs between men and women more than expected in view of the overall association between the two genders, suggesting a stronger relative importance in one gender group.