Table 1. Non-compartmental pharmacokinetic parameters of acyclovir after oral administrations of immediate release (IR) tablet, sustained release (SR) tablet, or gastroretentive (GR) system in Beagle dogs (n = 5).
| Parameters | IR tablet (n = 5) | SR tablet (n = 5) | GR system (n = 5) |
|---|---|---|---|
| Dose (mg) | 100 | 100 | 100 |
| t1/2 (h) | 3.22 ± 1.45 | 1.80 ± 0.17 | 4.47 ± 1.43 |
| Tmax (h) | 1.10 ± 0.22 | 1.70 ± 0.27* | 9.20 ± 2.68* |
| Cmax (μg/mL) | 5.84 ± 1.18 | 5.61 ± 0.38 | 2.80 ± 1.12* |
| AUCall (μg·h/mL) | 22.56 ± 3.05 | 20.84 ± 2.20 | 28.06 ± 6.05 |
| AUCinf (μg·h/mL) | 23.56 ± 2.95 | 21.16 ± 2.36 | 28.90 ± 5.52 |
| Vz/F (L) | 20.44 ± 11.08 | 12.32 ± 0.92 | 23.64 ± 10.82 |
| MRT (h) | 4.27 ± 1.23 | 3.49 ± 0.45 | 10.39 ± 2.13* |
| CL/F (mL/min) | 71.56 ± 8.12 | 79.55 ± 8.97 | 59.30 ± 10.73 |
| Frel (%) | - | 89.84 | 122.67 |
*, p<0.05 vs. IR reference tablet.