Table 2. Population pharmacokinetic parameter estimates of acyclovir immediate release (IR) tablet and gastroretentive (GR) system.
| Parameters | Mean (SE%) | BSV (SE%) |
|---|---|---|
| V1 (L) | 8.83 (12%) | 0.315 (56.2%) |
| V2 (L) | 3.47 (10.5%) | 0.11 (342%) |
| CL (L/h) | 4.57 (4.5%) | 0.123 (50.6%) |
| CLD (L/h) | 1.75 (4.1%) | 0.0336 (170%) |
| Tlag (h) | 0.0189 (55.1%) | 0.18 (200%) |
| Kdiss(0) (h-1) | 0.0683 (15.1%) | 0.161 (124%) |
| Tchange50 (h) | 6.15 (11.3%) | 0.285 (51.4%) |
| Dissmax | 7.86 (16.1%) | 0.256 (67.2%) |
| Hill | 10 (fixed) | 0 (fixed) |
| Ka,trans (h-1) | 2.63 (7.6%) | 0.267 (51.8%) |
| Ka (h-1) | 2.68 (10%) | 0.189 (54.1%) |
| Frel_IR | 1 (fixed) | 0.0234 (348%) |
| Frel_GR | 1.19 (8.5%) | 0.0404 (187%) |