Table 1.
Demographic and Clinical Characteristics of Samples
| Discovery |
Validation |
|||||
|---|---|---|---|---|---|---|
| Patient Characteristics | Malignant Nodule | Benign Nodule | P Value | Malignant Nodule | Benign Nodule | P Value |
| Age, yr | 73.2 | 60.2 | 0.07 | 64.6 | 62.7 | 0.059 |
| Sex | ||||||
| Male | 4 | 4 | 56 | 56 | ||
| Female | 6 | 6 | 69 | 69 | ||
| Race | ||||||
| White | 9 | 8 | 111 | 114 | ||
| African American | 0 | 1 | 2 | 2 | ||
| Asian | 1 | 1 | 8 | 6 | ||
| Other | 0 | 0 | 4 | 3 | ||
| Histology | ||||||
| NSCLC | 10 | — | 125 | — | ||
| AD | 7 | — | 104 | — | ||
| SCC | 3 | — | 18 | — | ||
| Smoking status | ||||||
| Current | 1 | 2 | 46 | 30 | ||
| Former | 7 | 7 | 62 | 68 | ||
| Never | 2 | 1 | 17 | 27 | ||
| Pack-years | 29.8 | 25.4 | 0.12 | 32.1 | 25.3 | 0.00018 |
| BMI | ||||||
| <24.9 kg/m2 | 5 | 4 | 49 | 43 | ||
| 25–29.9 kg/m2 | 1 | 3 | 41 | 42 | ||
| >30 kg/m2 | 4 | 3 | 35 | 39 | ||
| Unknown | 0 | 0 | 0 | 1 | ||
Definition of abbreviations: AD = adenocarcinoma; BMI = body mass index; NSCLC = non–small cell lung cancer; SCC = squamous cell carcinoma.
Tumor B-cell extracts were generated from malignant nodule patients. Plasma was analyzed from both nodule-positive cohorts. Age and pack-years are population means.