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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2018 May 16;27(7):728–736. doi: 10.1158/1055-9965.EPI-17-0573

Figure 2.

Figure 2

Cox 2 immunohistochemical staining

Figure contains immunohistochemical staining for Cox2 showed a wide spectrum of cytoplasmic reactivity ranging from no staining (A), weak staining (B) to diffuse strong staining (C) in the lesional adenoma cells. 15-PDGH immunostain was scored as loss of staining when cytoplasmic positivity was present only in the surface epithelium (D; red arrow) with no staining in the adenoma crypt epithelium (D; blue arrows). Note the positive staining in the stromal inflammatory cells (D) that served as an internal positive control. 15-PGDH was scored as positive when there was staining observed in >1% of cells in both surface and crypt epithelium and the intensity in these cases ranged from moderate (E) to strong (F).