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Astroglial alterations induced by Tkb1 deficiency. (A) GFAP immunostaining of the cerebellum of 5 and 14 months old mice (n = 3). Bar = 50 μm. Spheroidal astrocytes are indicated by arrows. (B) Quantification of astrocyte degeneration (n = 9); ***P < 0.001, compared to WT mice. (C) Double GFAP and p62 immunofluorescence of the cerebellum. Bar = 10 μm.
