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. 2019 Apr 19;11(8):2202–2216. doi: 10.18632/aging.101905

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Copyright © 2019 Fiorillo et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Combining low-dose Azithromycin and Doxycycline with Vitamin C (DAV), dramatically inhibits metabolism: Bar graphs. Note that the rate of oxidative mitochondrial metabolism was reduced by >50% and ATP levels were drastically reduced by >95%, as assessed using the Seahorse XFe96 analyzer. This resulted in significant reductions in both basal and maximal respiration. Note also that glycolysis was increased, while glycolytic reserve was decreased by the triple combination. ***p < 0.001; ****p < 0.0001.