Table 3. Multivariate logistic regression analysis for DVT according to MIF Quartiles.

MIF ǂ	DVT/N	Crude OR (95%CI), P	Multivariable-adjusted‡*, P
Quartile 1	3/52	Reference	Reference
Quartile 2	7/51	2.60(0.63–10.67), 0.018	—
Quartile 3	12/52	4.90(1.29–18.57), 0.012	3.10(1.05–9.33), 0.043
Quartile 4	17/52	7.93(2.16–29.16), <0.001	4.76(2.55–11.75), <0.001
Elevated vs. normal	17/52 vs. 22/155	2.94(1.41–6.12), 0.003	2.15(1.05–3.36), 0.015

^ǂ MIF in Quartile 1 (<17.4ng/ml), Quartile 2 (17.4–22.1ng/ml), Quartile 3 (22.2–27.8ng/ml), and Quartile 4 (>27.8ng/ml). Elevated MIF level was defined as greater than or equal to the 3^rd quartile level (≥27.8ng/ml).

^‡Adjusted for those significant risk factors which confirmed in the univariate analysis, including age, history of vein thrombosis, clinical complications, rehabilitation therapy, plasma levels of CRP, IL-6, D-dimer and MIF

^*P value for the trend <0.001

OR, odds ratio; CI, confidence interval; CRP, C-reactive protein; IL-6; Interleukin 6; MIF, Macrophage migration inhibitory factor; DVT: Deep vein thrombosis